Cytochrome B-245 Heavy Chain (CYBB) Antibody

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Catalogue No: abx001378
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
Cytochrome B-245 Heavy Chain (CYBB) Antibody is a Rabbit Polyclonal antibody against CYBB. Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008].

Target Cytochrome B-245 Heavy Chain (CYBB)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to a sequence within amino acids 385-570 of human NOX2/gp91phox.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P04839 (UniProt, ExPASy)
UniProt Secondary AC A8K138, Q2PP16
UniProt Entry Name CY24B_HUMAN
Gene Symbol CYBB
GeneID 1536
NCBI Accession NP_000388.2
KEGG hsa:1536
String 9606.ENSP00000367851
Molecular Weight Calculated MW: 65 kDa
Observed MW: 65 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cytochrome B-245 Heavy Chain (CYBB)


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