Cytochrome B-245 Heavy Chain (CYBB) Antibody
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Catalogue No: abx001378
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US$348.00
(Size: 60 µl)
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Datasheet SDS
Cytochrome B-245 Heavy Chain (CYBB) Antibody is a Rabbit Polyclonal antibody against CYBB. Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008].
Research Articles on Cytochrome B-245 Heavy Chain (CYBB)
| Target | Cytochrome B-245 Heavy Chain (CYBB) |
| Research Area | Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human NOX2/gp91phox |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04839 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K138, Q2PP16 |
| UniProt Entry Name | CY24B_HUMAN |
| Gene Symbol | CYBB |
| GeneID | 1536 |
| NCBI Accession | NP_000388.2 |
| KEGG | hsa:1536 |
| String | 9606.ENSP00000367851 |
| Molecular Weight | Calculated MW: 65 kDa Observed MW: 65 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
