Steroid 17-Alpha-Hydroxylase/17,20 Lyase (CYP17A1) Antibody

CYP17A1 Antibody is a Rabbit Polyclonal antibody against CYP17A1. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008].

Target	Steroid 17-Alpha-Hydroxylase/17,20 Lyase (CYP17A1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human CYP17A1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05093 (UniProt, ExPASy)
UniProt Secondary AC	Q5TZV7
UniProt Entry Name	CP17A_HUMAN
Gene Symbol	CYP17A1
GeneID	1586
NCBI Accession	NP_000093.1
KEGG	hsa:1586
String	9606.ENSP00000358903
Molecular Weight	Calculated MW: 57 kDa Observed MW: 57 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Steroid 17-Alpha-Hydroxylase/17,20 Lyase (CYP17A1)

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