Cytochrome P450 1A2 (CYP1A2) Antibody

CYP1A2 Antibody is a Rabbit Polyclonal antibody against CYP1A2. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Target	Cytochrome P450 1A2 (CYP1A2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 205-305 of human CYP1A2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05177 (UniProt, ExPASy)
UniProt Secondary AC	Q16754, Q6NWU3, Q6NWU5, Q9BXX7, Q9UK49
UniProt Entry Name	CP1A2_HUMAN
Gene Symbol	CYP1A2
GeneID	1544
NCBI Accession	NP_000752.2
KEGG	hsa:1544
String	9606.ENSP00000342007
Molecular Weight	Calculated MW: 58 kDa Observed MW: 54 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cytochrome P450 1A2 (CYP1A2)

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