+44 (0) 1223 755950
+1 832 327 7413
Cytochrome P450 27B1 (CYP27B1) Antibody
REQUEST MORE INFO
Catalogue No: abx034211
Price:
US$326.25
(Size: 50 µl)
Orders to United States ship from United States
(
Click on the image to see the image legend
Add to Cart
Buy It Now
GET A QUOTE
Documents
Datasheet SDS
CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha, 25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Research Articles on Cytochrome P450 27B1 (CYP27B1)
| Target | Cytochrome P450 27B1 (CYP27B1) |
| Research Area | Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/10 - 1/50, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human CYP27B1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O15528 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RC61, Q548T3 |
| UniProt Entry Name | CP27B_HUMAN |
| Gene Symbol | CYP27B1 |
| GeneID | 1594 |
| OMIM | 264700 |
| NCBI Accession | NP_000776.1 |
| HGNC | 2606 |
| KEGG | hsa:1594 |
| Ensembl | ENSG00000111012 |
| String | 9606.ENSP00000228606 |
| Molecular Weight | Calculated MW: 56.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |