Cytochrome P450 Family 2 Subfamily B Member 6 (CYP2B6) Antibody
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Catalogue No: abx026084
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US$326.25
(Size: 80 µl)
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Datasheet SDS
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Research Articles on Cytochrome P450 Family 2 Subfamily B Member 6 (CYP2B6)
| Target | Cytochrome P450 Family 2 Subfamily B Member 6 (CYP2B6) |
| Research Area | Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/10 - 1/50, IF/ICC: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P20813 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DWP3, Q2V565, Q9UK46 |
| UniProt Entry Name | CP2B6_HUMAN |
| Gene Symbol | CYP2B6 |
| GeneID | 1555 |
| OMIM | 123930 |
| NCBI Accession | NP_000758.1 |
| HGNC | 2615 |
| KEGG | hsa:1555 |
| Ensembl | ENSG00000197408 |
| String | 9606.ENSP00000324648 |
| Molecular Weight | Calculated MW: 56.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |