Cytochrome P450 2E1 (CYP2E1) Antibody

CYP2E1 Antibody is a Rabbit Polyclonal antibody against CYP2E1. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008].

Target	Cytochrome P450 2E1 (CYP2E1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 234-493 of human CYP2E1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05181 (UniProt, ExPASy)
UniProt Secondary AC	Q5VZD5, Q6NWT9, Q9UK47
UniProt Entry Name	CP2E1_HUMAN
Gene Symbol	CYP2E1
GeneID	1571
OMIM	124040
NCBI Accession	NP_000764.1
HGNC	2631
KEGG	hsa:1571
Ensembl	ENSG00000130649
String	9606.ENSP00000440689
Molecular Weight	Calculated MW: 57 kDa Observed MW: 55 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cytochrome P450 2E1 (CYP2E1)

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