7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase (CYP8B1) Antibody
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Catalogue No: abx034105
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(Size: 80 µl)
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Datasheet SDS
CYP8B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha, 12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.
Research Articles on 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase (CYP8B1)
| Target | 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase (CYP8B1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 471-501 amino acids from the C-terminal region of human CYP8B1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9UNU6 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RCY3, O75958, Q6NWT2, Q6NWT3 |
| UniProt Entry Name | CP8B1_HUMAN |
| Gene Symbol | CYP8B1 |
| GeneID | 1582 |
| OMIM | 602172 |
| NCBI Accession | NP_004382.2 |
| HGNC | 2653 |
| KEGG | hsa:1582 |
| Ensembl | ENSG00000180432 |
| String | 9606.ENSP00000318867 |
| Molecular Weight | Calculated MW: 58.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |