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Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Antibody

Catalogue No: abx001028
Price: £120.00
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CYR61 Antibody is a Rabbit Polyclonal antibody against CYR61. Cyr61 is a secreted heparin binding protein, encoded by a growth factor-inducible immediate-early gene, that associates with the extracellular matrix and connective tissue. Cyr61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse Cyr61 homolog, Fisp12. As an angiogenic inducer, Cyr61 binds to the cell surface receptor Integrin aV/b3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of Cyr61 is elevated during vessel growth, wound healing and chondrocyte differentiation. Cyr61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

Target CYR61
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human CYR61.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O00622 (UniProt, ExPASy)
UniProt Secondary AC O14934, O43775, Q9BZL7
UniProt Entry Name CCN1_HUMAN
Gene Symbol CCN1
GeneID 3491
KEGG hsa:349
String 9606.ENSP00000398736
Molecular Weight Calculated MW: 42 kDa
Observed MW: 42 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Antibody

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