Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Antibody

CYR61 Antibody is a Rabbit Polyclonal antibody against CYR61. Cyr61 is a secreted heparin binding protein, encoded by a growth factor-inducible immediate-early gene, that associates with the extracellular matrix and connective tissue. Cyr61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse Cyr61 homolog, Fisp12. As an angiogenic inducer, Cyr61 binds to the cell surface receptor Integrin aV/b3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of Cyr61 is elevated during vessel growth, wound healing and chondrocyte differentiation. Cyr61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

Target	Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 120-220 of human CYR61.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00622 (UniProt, ExPASy)
UniProt Secondary AC	O14934, O43775, Q9BZL7
UniProt Entry Name	CCN1_HUMAN
Gene Symbol	CCN1
GeneID	3491
NCBI Accession	NP_001545.2
KEGG	hsa:3491
String	9606.ENSP00000398736
Molecular Weight	Calculated MW: 42 kDa Observed MW: 41 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)

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