Cytochrome C (CYCS) Antibody

Cytochrome C (CYCS) Antibody is a Mouse Monoclonal antibody for the detection of Cytochrome c.

Cytochrome c is a 12-15 kDa electron transporting protein located in the inner mitochondrial membrane. Upon apoptotic stimulation, cytochrome c can be released from mitochondria into cytoplasm, resulting in caspase-3 activation and apoptosis. Measurement of cytochrome c release from the mitochondria is useful for detection of the onset of apoptosis in cells. In addition, cytochrome c can also leave cells and be detectable in extra-cellular medium of apoptotic cells and serum of cancer patients. The level of serum cytochrome c may serve as a prognostic maker during cancer therapy.

Target	Cytochrome C (CYCS)
Research Area	Metabolism
Clonality	Monoclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	WB: 1/5000 - 1/30000, IHC: 1/100 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Cytochrome c
Isotype	IgG2a
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life	12 months.
UniProt Primary AC	P99999 (UniProt, ExPASy)
UniProt Secondary AC	A4D166, B2R4I1, P00001, Q6NUR2, Q6NX69, Q96BV4
UniProt Entry Name	CYC_HUMAN
Gene Symbol	CYCS
GeneID	54205
OMIM	123970
HGNC	19986
KEGG	hsa:54205
Ensembl	ENSG00000172115
String	9606.ENSP00000307786
Molecular Weight	Observed MW: 12 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Cytochrome C (CYCS)

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