Netrin Receptor DCC (DCC) Antibody

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Target	Netrin Receptor DCC (DCC)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43146 (UniProt, ExPASy)
UniProt Entry Name	DCC_HUMAN
Gene Symbol	DCC
KEGG	hsa:1630
String	9606.ENSP00000389140
Molecular Weight	Calculated MW: 158 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat DCC.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Netrin Receptor DCC (DCC)

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