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Dynactin Subunit 1 (DCTN1) Antibody
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Catalogue No: abx001479
Price:
£120.00
(Size: 20 µl)
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DCTN1 Antibody is a Rabbit Polyclonal antibody against DCTN1. This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008].
Research Articles on DCTN1
| Target | DCTN1 |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/100, IP: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein of human DCTN1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14203 (UniProt, ExPASy) |
| UniProt Entry Name | DCTN1_HUMAN |
| Gene Symbol | DCTN1 |
| GeneID | 1639 |
| KEGG | hsa:1639 |
| String | 9606.ENSP00000354791 |
| Molecular Weight | Calculated MW: 126 kDa, 127 kDa, 136 kDa, 138 kDa, 140 kDa, 141 kDa Observed MW: 175 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
