Dynactin Subunit 2 (DCTN2) Antibody

DCTN2 Antibody is a Rabbit Polyclonal antibody against DCTN2. Dynamitin is a 50 kDa protein containing a calmodulin binding domain, a putative ATPase domain and MacMARCKS-binding domain. This protein is a part of the dynactin complex believed to link the dynactin complex to membrane compartments. Its functions are tightly associated with dynein motor protein, thus extend to vesicle trafficking and membrane integrity. Dynamitin was named so because its overexpression causes dynactin complex which contains 10 subunits, to disassemble. Its N terminal 58 amino acid is for MacMARCKS binding and residues 59-83 is responsible for calmodulin binding. This antibody is against the full length p50 dynamitin.

Target	Dynactin Subunit 2 (DCTN2)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 50-320 of human DCTN2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13561 (UniProt, ExPASy)
UniProt Secondary AC	B2RBK5, Q86YN2, Q9BW17
UniProt Entry Name	DCTN2_HUMAN
Gene Symbol	DCTN2
GeneID	10540
NCBI Accession	NP_006391.1
KEGG	hsa:10540
String	9606.ENSP00000408910
Molecular Weight	Calculated MW: 44 kDa Observed MW: 44 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dynactin Subunit 2 (DCTN2)

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