DNA Damage Inducible Transcript 3 (DDIT3) Antibody

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Target	DNA Damage Inducible Transcript 3 (DDIT3)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of human DDIT3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35638 (UniProt, ExPASy)
UniProt Secondary AC	F8VS99
UniProt Entry Name	DDIT3_HUMAN
Gene Symbol	DDIT3
KEGG	hsa:1649
String	9606.ENSP00000448665
Molecular Weight	Calculated MW: 19.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Hamster DDIT3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA Damage Inducible Transcript 3 (DDIT3)

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