Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2) Antibody

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq]. This antibody is supplied as crude ascites.

Target	Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/100 - 1/1600, IHC: 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 290-320 amino acids from human DDR2.
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q16832 (UniProt, ExPASy)
UniProt Secondary AC	Q7Z730
UniProt Entry Name	DDR2_HUMAN
KEGG	hsa:4921
String	9606.ENSP00000356899
Molecular Weight	Calculated MW: 96.7 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue