Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2) Antibody
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Catalogue No: abx025427
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US$623.50
(Size: 100 µl)
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Datasheet SDS
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq]. This antibody is supplied as crude ascites.
Research Articles on Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2)
| Target | Discoidin Domain Receptor Tyrosine Kinase 2 (DDR2) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/100 - 1/1600, IHC: 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 290-320 amino acids from human DDR2. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified crude ascites. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q16832 (UniProt, ExPASy) |
| UniProt Secondary AC | Q7Z730 |
| UniProt Entry Name | DDR2_HUMAN |
| KEGG | hsa:4921 |
| String | 9606.ENSP00000356899 |
| Molecular Weight | Calculated MW: 96.7 kDa |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |