Dihydrofolate Reductase (DHFR) Antibody

DHFR Antibody is a Rabbit Polyclonal antibody against DHFR. Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq, Jul 2008].

Target	Dihydrofolate Reductase (DHFR)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human DHFR.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P00374 (UniProt, ExPASy)
UniProt Secondary AC	B4DDD2, Q14130, Q6IRW8
UniProt Entry Name	DYR_HUMAN
Gene Symbol	DHFR
GeneID	1719
NCBI Accession	NP_000782.1
KEGG	hsa:1719
String	9606.ENSP00000396308
Molecular Weight	Calculated MW: 21 kDa Observed MW: 19 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dihydrofolate Reductase (DHFR)

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