Second Mitochondria-Derived Activator of Caspase / SMAC (DIABLO) Antibody

DIABLO Antibody is a Rabbit Polyclonal antibody against DIABLO. This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target	Second Mitochondria-Derived Activator of Caspase / SMAC (DIABLO)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IP: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NR28 (UniProt, ExPASy)
UniProt Secondary AC	B2RDQ0, Q6W3F3, Q96LV0, Q9BT11, Q9HAV6
UniProt Entry Name	DBLOH_HUMAN
Gene Symbol	DIABLO
GeneID	56616
NCBI Accession	NP_063940.1
String	9606.ENSP00000398495
Molecular Weight	Calculated MW: 27 kDa Observed MW: 18 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Second Mitochondria-Derived Activator of Caspase / SMAC (DIABLO)

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