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H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody

Catalogue No: abx001537
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H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody

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DKC1 Antibody is a Rabbit Polyclonal antibody against DKC1. This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].

Target DKC1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human DKC1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O60832 (UniProt, ExPASy)
UniProt Secondary AC F5BSB3, O43845, Q96G67, Q9Y505
UniProt Entry Name DKC1_HUMAN
Gene Symbol DKC1
GeneID 1736
KEGG hsa:1736
String 9606.ENSP00000358563
Molecular Weight Calculated MW: 47 kDa, 57 kDa
Observed MW: 43 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on H/ACA Ribonucleoprotein Complex Subunit DKC1 (DKC1) Antibody

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