DNA Repair Protein Complementing XP-G Cells (ERCC5) Antibody

ERCC5 Antibody is a Rabbit Polyclonal antibody against ERCC5. This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011].

Target	DNA Repair Protein Complementing XP-G Cells (ERCC5)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	IF/ICC
Host	Rabbit
Recommended dilutions	IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ERCC5.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P28715 (UniProt, ExPASy)
UniProt Entry Name	ERCC5_HUMAN
Gene Symbol	ERCC5
GeneID	2073
NCBI Accession	NP_000114.2
KEGG	hsa:2073
String	9606.ENSP00000347978
Molecular Weight	Calculated MW: 133 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA Repair Protein Complementing XP-G Cells (ERCC5)

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