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DNA Repair Protein Complementing XP-G Cells (ERCC5) Antibody

Catalogue No: abx001349
Price: £120.00
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DNA Repair Protein Complementing XP-G Cells (ERCC5) Antibody

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ERCC5 Antibody is a Rabbit Polyclonal antibody against ERCC5. This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011].

Target ERCC5
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human ERCC5.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P28715 (UniProt, ExPASy)
UniProt Entry Name ERCC5_HUMAN
Gene Symbol ERCC5
GeneID 2073
KEGG hsa:2073
String 9606.ENSP00000347978
Molecular Weight Calculated MW: 27 kDa, 47 kDa, 133 kDa
Observed MW: 133 kDa
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on DNA Repair Protein Complementing XP-G Cells (ERCC5) Antibody

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