Deoxyribonuclease-1 (DNASE1) Antibody

DNASE1 Antibody is a Rabbit Polyclonal antibody against DNASE1. This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Target	Deoxyribonuclease-1 (DNASE1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 22-282 of human DNASE1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P24855 (UniProt, ExPASy)
UniProt Secondary AC	B4DV35, Q14UU9, Q14UV0
UniProt Entry Name	DNAS1_HUMAN
Gene Symbol	DNASE1
GeneID	1773
NCBI Accession	NP_005214.2
KEGG	hsa:1773
String	9606.ENSP00000385905
Molecular Weight	Calculated MW: 31 kDa Observed MW: 32 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Deoxyribonuclease-1 (DNASE1)

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