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Deoxyribonuclease I (DNASE1) Antibody

Catalogue No: abx001975
Price: £120.00
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Deoxyribonuclease I (DNASE1) Antibody Deoxyribonuclease I (DNASE1) Antibody

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DNASE1 Antibody is a Rabbit Polyclonal antibody against DNASE1. This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Target DNASE1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human DNASE1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P24855 (UniProt, ExPASy)
UniProt Secondary AC B4DV35, Q14UU9, Q14UV0
UniProt Entry Name DNAS1_HUMAN
Gene Symbol DNASE1
GeneID 1773
KEGG hsa:1773
String 9606.ENSP00000385905
Molecular Weight Calculated MW: 19 kDa, 31 kDa
Observed MW: 37 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Deoxyribonuclease I (DNASE1) Antibody

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