DNA Methyltransferase 3 Alpha (DNMT3A) Antibody

DNMT3A Antibody is a Rabbit Polyclonal antibody against DNMT3A. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target	DNA Methyltransferase 3 Alpha (DNMT3A)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/20. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 500-700 of human DNMT3A.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y6K1 (UniProt, ExPASy)
UniProt Secondary AC	E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9
UniProt Entry Name	DNM3A_HUMAN
Gene Symbol	DNMT3A
GeneID	1788
NCBI Accession	NP_072046.2
String	9606.ENSP00000264709
Molecular Weight	Calculated MW: 102 kDa Observed MW: 95 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA Methyltransferase 3 Alpha (DNMT3A)

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