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DNA Methyltransferase 3 Beta (DNMT3B) Antibody

Catalogue No: abx002130
Price: £120.00
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DNA Methyltransferase 3 Beta (DNMT3B) Antibody

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DNMT3B Antibody is a Rabbit Polyclonal antibody against DNMT3B. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011].

Target DNMT3B
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human DNMT3B.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UBC3 (UniProt, ExPASy)
UniProt Entry Name DNM3B_HUMAN
Gene Symbol DNMT3B
GeneID 1789
String 9606.ENSP00000328547
Molecular Weight Calculated MW: 77-95 kDa
Observed MW: 96 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on DNA Methyltransferase 3 Beta (DNMT3B) Antibody

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