DNA Methyltransferase 3 Like (DNMT3L) Antibody
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Catalogue No: abx001899
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US$348.00
(Size: 60 µl)
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Datasheet SDS
DNMT3L Antibody is a Rabbit Polyclonal antibody against DNMT3L. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on DNA Methyltransferase 3 Like (DNMT3L)
| Target | DNA Methyltransferase 3 Like (DNMT3L) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human DNMT3L |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9UJW3 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PB42, Q9BUJ4 |
| UniProt Entry Name | DNM3L_HUMAN |
| Gene Symbol | DNMT3L |
| GeneID | 29947 |
| NCBI Accession | NP_787063.1 |
| String | 9606.ENSP00000270172 |
| Molecular Weight | Calculated MW: 43 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
