Docking Protein 1 (DOK1) Antibody

DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Target	Docking Protein 1 (DOK1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human DOK1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q99704 (UniProt, ExPASy)
UniProt Secondary AC	O43204, Q53TY2, Q9UHG6
UniProt Entry Name	DOK1_HUMAN
KEGG	hsa:1796
String	9606.ENSP00000233668
Molecular Weight	Calculated MW: 52.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow DOK1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Docking Protein 1 (DOK1)

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