Dihydropyrimidine Dehydrogenase (DPYD) Antibody

DPYD Antibody is a Rabbit Polyclonal antibody against DPYD. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Target	Dihydropyrimidine Dehydrogenase (DPYD)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q12882 (UniProt, ExPASy)
UniProt Entry Name	DPYD_HUMAN
Gene Symbol	DPYD
GeneID	1806
NCBI Accession	NP_000101.2
KEGG	hsa:1806
String	9606.ENSP00000359211
Molecular Weight	Calculated MW: 111 kDa Observed MW: 112 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dihydropyrimidine Dehydrogenase (DPYD)

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