Down Syndrome Critical Region Protein 1 (DSCR1) Antibody
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Catalogue No: abx025110
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US$326.25
(Size: 80 µl)
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Datasheet SDS
DSCR1 (calcipressin 1) interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. Thr gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.
Research Articles on Down Syndrome Critical Region Protein 1 (DSCR1)
| Target | Down Syndrome Critical Region Protein 1 (DSCR1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 75-104 amino acids from the Central region of human DSCR1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P53805 (UniProt, ExPASy) |
| UniProt Entry Name | RCAN1_HUMAN |
| KEGG | hsa:1827 |
| String | 9606.ENSP00000370527 |
| Molecular Weight | Calculated MW: 28.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |