Down Syndrome Critical Region Protein 3 (DSCR3) Antibody

The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined.

Target	Down Syndrome Critical Region Protein 3 (DSCR3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DSCR3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14972 (UniProt, ExPASy)
UniProt Secondary AC	B2R6T8, B7Z6B1, D3DSH4, Q2TAY6
UniProt Entry Name	VP26C_HUMAN
Gene Symbol	VPS26C
KEGG	hsa:10311
String	9606.ENSP00000311399
Molecular Weight	Calculated MW: 33 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Down Syndrome Critical Region Protein 3 (DSCR3)

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