Dual Specificity Phosphatase 4 (DUSP4) Antibody

DUSP4 Antibody is a Rabbit Polyclonal antibody against DUSP4. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Target	Dual Specificity Phosphatase 4 (DUSP4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DUSP4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13115 (UniProt, ExPASy)
UniProt Secondary AC	B2RBU5, D3DSU4, G5E930, Q13524
UniProt Entry Name	DUS4_HUMAN
Gene Symbol	DUSP4
GeneID	1846
NCBI Accession	NP_001385.1
KEGG	hsa:1846
String	9606.ENSP00000240100
Molecular Weight	Calculated MW: 43 kDa Observed MW: 47 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dual Specificity Phosphatase 4 (DUSP4)

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