Dual Specificity Phosphatase 6 (DUSP6) Antibody

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene.

Target	Dual Specificity Phosphatase 6 (DUSP6)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/500, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 58-89 amino acids from the Central region of human DUSP6.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q16828 (UniProt, ExPASy)
UniProt Secondary AC	O75109, Q53Y75, Q9BSH6
UniProt Entry Name	DUS6_HUMAN
KEGG	hsa:1848
String	9606.ENSP00000279488
Molecular Weight	Calculated MW: 42.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow DUSP6.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dual Specificity Phosphatase 6 (DUSP6)

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