Dual Specificity Phosphatase 6 (DUSP6) Antibody

Catalogue No: abx002274
Price: £120.00
(Size: 20 µl)
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Dual Specificity Phosphatase 6 (DUSP6) Antibody

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DUSP6 Antibody is a Rabbit Polyclonal antibody against DUSP6. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Target DUSP6
Clonality Polyclonal
Reactivity Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human DUSP6.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q16828 (UniProt, ExPASy)
UniProt Secondary AC O75109, Q53Y75, Q9BSH6
UniProt Entry Name DUS6_HUMAN
Gene Symbol DUSP6
GeneID 1848
KEGG hsa:1848
String 9606.ENSP00000279488
Molecular Weight Calculated MW: 26 kDa, 42 kDa
Observed MW: 42 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Dual Specificity Phosphatase 6 (DUSP6) Antibody

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