3-Beta Hydroxysteroid-Delta-8, Delta-7 Isomerase (EBP) Antibody

The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).

Target	3-Beta Hydroxysteroid-Delta-8, Delta-7 Isomerase (EBP)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 201-230 amino acids from the C-terminal region of human EBP.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15125 (UniProt, ExPASy)
UniProt Secondary AC	Q6FGL3, Q6IBI9
UniProt Entry Name	EBP_HUMAN
Gene Symbol	EBP
GeneID	10682
OMIM	300205
HGNC	3133
KEGG	hsa:10682
Ensembl	ENSG00000147155
String	9606.ENSP00000417052
Molecular Weight	Calculated MW: 26.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 3-Beta Hydroxysteroid-Delta-8, Delta-7 Isomerase (EBP)

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