Endothelin 3 (EDN3) Antibody

EDN3 Antibody is a Rabbit Polyclonal antibody against EDN3. The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

Target	Endothelin 3 (EDN3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 17-187 of human EDN3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P14138 (UniProt, ExPASy)
UniProt Secondary AC	E1P5I5, Q03229, Q7Z6D2, Q9UGT7
UniProt Entry Name	EDN3_HUMAN
Gene Symbol	EDN3
GeneID	1908
NCBI Accession	NP_996917.1
KEGG	hsa:1908
String	9606.ENSP00000337128
Molecular Weight	Calculated MW: 25 kDa Observed MW: 44 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Endothelin 3 (EDN3)

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