EF-Hand Calcium Binding Domain 4B (EFCAB4B) Antibody

Ca (2+) binding protein that plays a key role in store-operated Ca (2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca (2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca (2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Target	EF-Hand Calcium Binding Domain 4B (EFCAB4B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9BSW2 (UniProt, ExPASy)
UniProt Secondary AC	B4E1X0, B9EK63
UniProt Entry Name	EFC4B_HUMAN
Gene Symbol	CRACR2A
String	9606.ENSP00000409382
Molecular Weight	Calculated MW: 83.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on EF-Hand Calcium Binding Domain 4B (EFCAB4B)

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