EGFR (pY1016) Antibody

Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. EGFR is a receptor for EGF, but also for other members of the EGF family, including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. It is involved in the control of cell growth and differentiation.

Target	EGFR (pY1016)
Clonality	Polyclonal
Target Modification	Tyr1016
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, WB, DB
Host	Rabbit
Recommended dilutions	WB: 1/8000, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1016 of human EGFR.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P00533 (UniProt, ExPASy)
UniProt Entry Name	EGFR_HUMAN
KEGG	hsa:1956
String	9606.ENSP00000275493
Molecular Weight	Calculated MW: 134 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse EGFR.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on EGFR (pY1016)

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