Egl Nine Homolog 1 (EGLN1) Antibody

EGLN1 Antibody is a Rabbit Polyclonal antibody against EGLN1. The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Target	Egl Nine Homolog 1 (EGLN1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/100, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human PHD2/EGLN1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9GZT9 (UniProt, ExPASy)
UniProt Secondary AC	Q8N3M8, Q9BZS8, Q9BZT0
UniProt Entry Name	EGLN1_HUMAN
Gene Symbol	EGLN1
GeneID	54583
NCBI Accession	NP_071334.1
String	9606.ENSP00000355601
Molecular Weight	Calculated MW: 46 kDa Observed MW: 45 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Egl Nine Homolog 1 (EGLN1)

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