Endoglin / CD105 (ENG) Antibody

Endoglin / CD105 (ENG) Antibody is a Rabbit Polyclonal antibody for the detection of CD105.

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Endoglin / CD105 (ENG)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	endoglin
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P17813 (UniProt, ExPASy)
UniProt Secondary AC	Q14248, Q14926, Q5T9C0
UniProt Entry Name	EGLN_HUMAN
Gene Symbol	ENG
GeneID	2022
OMIM	131195
HGNC	3349
KEGG	hsa:2022
Ensembl	ENSG00000106991
String	9606.ENSP00000362299
Molecular Weight	Observed MW: 75-90 kDa, 170-180 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Endoglin / CD105 (ENG)

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