Endoplasmic Reticulum-Associated Amyloid Beta-Peptide-Binding Protein (ERAB) Antibody

Endoplasmic Reticulum-Associated Amyloid Beta-Peptide-Binding Protein (ERAB) Antibody is a Rabbit Polyclonal antibody for the detection of ERAB.

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Target	Endoplasmic Reticulum-Associated Amyloid Beta-Peptide-Binding Protein (ERAB)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	hydroxysteroid(17-beta) dehydrogenase 10
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q99714 (UniProt, ExPASy)
UniProt Secondary AC	Q5H927, Q6IBS9, Q8TCV9, Q96HD5
Gene Symbol	HSD17B10
GeneID	3028
OMIM	300256
HGNC	4800
Ensembl	ENSG00000072506
Molecular Weight	Observed MW: 27 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Endoplasmic Reticulum-Associated Amyloid Beta-Peptide-Binding Protein (ERAB)

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