E1A Binding Protein P300 (EP300) Antibody
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Catalogue No: abx011304
Price:
US$427.75
(Size: 100 µl)
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Datasheet SDS
p300 is a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2.
Research Articles on E1A Binding Protein P300 (EP300)
| Target | E1A Binding Protein P300 (EP300) |
| Research Area | Tumor Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of EP300 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q09472 (UniProt, ExPASy) |
| UniProt Secondary AC | B1AKC2 |
| UniProt Entry Name | EP300_HUMAN |
| Gene Symbol | EP300 |
| GeneID | 2033 |
| OMIM | 602700 |
| HGNC | 3373 |
| KEGG | hsa:2033 |
| Ensembl | ENSG00000100393 |
| String | 9606.ENSP00000263253 |
| Enzyme Commission Number | EC 2.3.1.48 |
| Molecular Weight | 300 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |