EPH Receptor A2 (EphA2) Antibody

EPH receptor A2 (EphA2), with 976-amino acid protein (about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB1, EphB2, EphB3, EphB4 and EphB6 are Eph family receptors for Ephrin family ligands. In normal cells, EphA2 negatively regulates cell growth and invasiveness. EphA2 is overexpressed by many human cancers, and is often associated with poor prognostic features. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers.EphA2 may serve as a novel target for bladder cancer, colonic adenocarcinoma and ovarian cancer therapy.

Target	EPH Receptor A2 (EphA2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of EphA2 expressed in E. coli.
Isotype	IgM
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P29317 (UniProt, ExPASy)
UniProt Secondary AC	B5A968, Q8N3Z2
UniProt Entry Name	EPHA2_HUMAN
Gene Symbol	EPHA2
GeneID	1969
OMIM	116600
HGNC	3386
KEGG	hsa:1969
Ensembl	ENSG00000142627
String	9606.ENSP00000351209
Molecular Weight	120 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on EPH Receptor A2 (EphA2)

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