Erythropoietin Receptor (EPOR) Antibody

EPOR Antibody is a Rabbit Polyclonal antibody against EPOR. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

Target	Erythropoietin Receptor (EPOR)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 274-508 of human EPOR.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P19235 (UniProt, ExPASy)
UniProt Secondary AC	B2RCG4, Q15443, Q2M205
UniProt Entry Name	EPOR_HUMAN
Gene Symbol	EPOR
GeneID	2057
NCBI Accession	NP_000112.1
KEGG	hsa:2057
String	9606.ENSP00000222139
Molecular Weight	Calculated MW: 55 kDa Observed MW: 60 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Erythropoietin Receptor (EPOR)

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