Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody

ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian).This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.This protein has no ligand binding domain of its own and therefore cannot bind growth factors.However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here.Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Target	Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04626 (UniProt, ExPASy)
UniProt Secondary AC	B2RZG3, B4DHN3, Q14256, Q6LDV1, Q9UMK4, X5D2V5
UniProt Entry Name	ERBB2_HUMAN
Gene Symbol	ERBB2
GeneID	2064
OMIM	137800
HGNC	3430
KEGG	hsa:2064
Ensembl	ENSG00000141736
String	9606.ENSP00000269571
Molecular Weight	180 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)

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