Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody (FITC)
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Catalogue No: abx107283
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US$188.50
(Size: 20 µg)
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Datasheet SDS
ERBB2 Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC against ERBB2. ERBB2 is a protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. It is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. It regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Research Articles on Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)
| Target | Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) |
| Research Area | Signal Transduction, Tumor Immunity, Reproductive Science, Hepatology, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Host | Rabbit |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | FITC |
| Excitation/Emission | 499/515 |
| Laser Line | 488 |
| Immunogen | Recombinant human Receptor tyrosine-protein kinase erbB-2 protein (153-598AA). |
| Isotype | IgG |
| Form | Liquid |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04626 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RZG3, B4DHN3, Q14256, Q6LDV1, Q9UMK4, X5D2V5 |
| UniProt Entry Name | ERBB2_HUMAN |
| Gene Symbol | ERBB2 |
| GeneID | 2064 |
| OMIM | 137800 |
| NCBI Accession | NP_001005862.1 NM_001005862.2 |
| KEGG | hsa:2064 |
| String | 9606.ENSP00000269571 |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |