Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody

ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues.

Target	Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1227-1255 amino acids from the C-terminal region of human ERBB2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04626 (UniProt, ExPASy)
UniProt Secondary AC	B2RZG3, B4DHN3, Q14256, Q6LDV1, Q9UMK4, X5D2V5
UniProt Entry Name	ERBB2_HUMAN
KEGG	hsa:2064
String	9606.ENSP00000269571
Molecular Weight	Calculated MW: 138 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat ERBB2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue