ERBB2 (pY1223) Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Target	ERBB2 (pY1223)
Clonality	Polyclonal
Target Modification	Tyr1223
Modification	Phosphorylation
Reactivity	Mouse
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1223 of mouse ERBB2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P70424 (UniProt, ExPASy)
UniProt Secondary AC	Q61525, Q6ZPE0
UniProt Entry Name	ERBB2_MOUSE
KEGG	mmu:13866
String	10090.ENSMUSP00000053897
Molecular Weight	Calculated MW: 139 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat Erbb2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ERBB2 (pY1223)

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