V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) Antibody

ERBB3: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian).This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases.This membrane-bound protein has a neuregulin binding domain but not an active kinase domain.It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation.However, it does form heterodimers with other EGF receptor family members which do have kinase activity.Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors.Alternate transcriptional splice variants encoding different isoforms have been characterized.One isoform lacks the intermembrane region and is secreted outside the cell.This form acts to modulate the activity of the membrane-bound form.Additional splice variants have also been reported, but they have not been thoroughly characterized.

Target	V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21860 (UniProt, ExPASy)
UniProt Secondary AC	A8K6L6, B4DIK7, B4DV32, E9PDT8, Q9BUD7
UniProt Entry Name	ERBB3_HUMAN
Gene Symbol	ERBB3
GeneID	2065
OMIM	133180
HGNC	3431
KEGG	hsa:2065
Ensembl	ENSG00000065361
String	9606.ENSP00000267101
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)

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