V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) Antibody

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Catalogue No: abx000910
Price: US$232.00
(Size: 20 µl)

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Datasheet SDS
ERBB3 Antibody is a Rabbit Polyclonal antibody against ERBB3. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Target V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1275-1342 of human ErbB3/HER3.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P21860 (UniProt, ExPASy)
UniProt Secondary AC A8K6L6, B4DIK7, B4DV32, E9PDT8, Q9BUD7
UniProt Entry Name ERBB3_HUMAN
Gene Symbol ERBB3
GeneID 2065
NCBI Accession NP_001973.2
KEGG hsa:2065
String 9606.ENSP00000267101
Molecular Weight Calculated MW: 148 kDa
Observed MW: 185 kDa
Buffer PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)


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