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Transcriptional Regulator ERG (ERG) Antibody

Catalogue No: abx001152
Price: £120.00
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Transcriptional Regulator ERG (ERG) Antibody

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ERG Antibody is a Rabbit Polyclonal antibody against ERG. This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2012].

Target ERG
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human ERG.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P11308 (UniProt, ExPASy)
UniProt Secondary AC B4DTW5, B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
UniProt Entry Name ERG_HUMAN
Gene Symbol ERG
GeneID 2078
String 9606.ENSP00000414150
Molecular Weight Calculated MW: 35 kDa, 36 kDa, 41 kDa, 52 kDa, 53 kDa, 54 kDa
Observed MW: 60 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Transcriptional Regulator ERG (ERG) Antibody

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