Exoribonuclease 2 / EXOD1 (ERI2) Antibody

EXOD1 (Exonuclease domain-containing protein 1), also known as ERI2 (ERI1 exoribonuclease 2), is a 691 amino acid protein that contains one exonuclease domain, which catalyzes the hydrolysis of unpaired or mismatched nucleotides. EXOD1 acitivity is dependent on the binding of two magnesium ions per subunit. There are four isoforms of EXOD1 that are produced as a result of alternative splicing events. The gene encoding EXOD1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Target	Exoribonuclease 2 / EXOD1 (ERI2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 444-472 amino acids from the Central region of human ERI2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	A8K979 (UniProt, ExPASy)
UniProt Secondary AC	Q6ZSJ2, Q96FR9, Q9P224, Q9Y6V3
UniProt Entry Name	ERI2_HUMAN
Gene Symbol	ERI2
KEGG	hsa:112479
String	9606.ENSP00000350651
Molecular Weight	Calculated MW: 77.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Exoribonuclease 2 / EXOD1 (ERI2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue