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MAPK1 Antibody is a Rabbit Polyclonal antibody against MAPK1. This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Research Articles on Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody
||Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1)
||Human, Mouse, Rat
||WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
||Synthetic peptide. N term -peptide of human MAPK1.
||Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
|UniProt Primary AC
||Calculated MW: 36 kDa, 41 kDa
Observed MW: Refer to figures
||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
||> 1 mg/ml
||Shipped within 5-10 working days.
||This product is for research use only.