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Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody
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Catalogue No: abx000614
Price:
US$232.00
(Size: 20 µl)
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(![Western blot analysis of various lysates using [KO Validated] ERK2 Antibody at 1/1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 10s.](https://www.abbexa.com/image/cache/data/products/18B/abx000614_1-500x500.jpg "Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody")
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Datasheet SDS
MAPK1 Antibody is a Rabbit Polyclonal antibody against MAPK1. This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Research Articles on Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1)
| Target | Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) |
| Research Area | Signal Transduction, Enzymes and Kinases, Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to MAPK1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P28482 (UniProt, ExPASy) |
| UniProt Secondary AC | A8CZ64 |
| UniProt Entry Name | MK01_HUMAN |
| Gene Symbol | MAPK1 |
| GeneID | 5594 |
| NCBI Accession | NP_002736.3 |
| KEGG | hsa:5594 |
| String | 9606.ENSP00000215832 |
| Molecular Weight | Calculated MW: 41 kDa Observed MW: 42 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |