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Mitogen-Activated Protein Kinase 1 Phospho-Thr185/Tyr187 and 3 Phospho-Thr202/Tyr204 (MAPK1 pT185/Y187/MAPK3 pT202/Y204) Antibody
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Catalogue No: abx000517
Price:
US$232.00
(Size: 20 µl)
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Erk1 (pT202/Y204) / Erk2 (pT185/Y187) Antibody is a Rabbit Polyclonal antibody against Erk1 (pT202/Y204) / Erk2 (pT185/Y187). The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Research Articles on Mitogen-Activated Protein Kinase 1 Phospho-Thr185/Tyr187 and 3 Phospho-Thr202/Tyr204 (MAPK1 pT185/Y187 / MAPK3 pT202/Y204)
| Target | Mitogen-Activated Protein Kinase 1 Phospho-Thr185/Tyr187 and 3 Phospho-Thr202/Tyr204 (MAPK1 pT185/Y187 / MAPK3 pT202/Y204) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around T185 & Y187 of human ERK2MAPK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P28482 (UniProt, ExPASy) P27361 (UniProt, ExPASy) |
| UniProt Secondary AC | A8CZ58, B0LPG3, Q8NHX1 |
| UniProt Entry Name | MK03_HUMAN |
| Gene Symbol | MAPK1, MAPK3 |
| GeneID | 5594/5595 |
| NCBI Accession | NP_002736.3 |
| String | 9606.ENSP00000263025 |
| Molecular Weight | Calculated MW: 36/41/38/40/43 kDa Observed MW: 44 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
