Estrogen Receptor (ESR1) Antibody

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Target	Estrogen Receptor (ESR1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Human ESR1 recombinant protein.
Isotype	IgM Kappa
Form	Liquid
Purification	Purified by Euglobin precipitation followed by dialysis against deionized water.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P03372 (UniProt, ExPASy)
UniProt Secondary AC	Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7
UniProt Entry Name	ESR1_HUMAN
KEGG	hsa:2099
String	9606.ENSP00000405330
Molecular Weight	Calculated MW: 66.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Estrogen Receptor (ESR1)

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